lunes, 7 de enero de 2013

Escuela Superior de Medicina del Instituto Politécnico Nacional


Profesor/Investigador Titular C, Escuela Superior de Medicina del Instituto Politécnico Nacional
SNI III

Tel: 57296300 ext 62820 o 63919915

Email: rmcoralv@gmail.com, rcoral@ipn.mx


Alumnos Graduados


Alumnos graduados:

Diez alumnos de Doctorado

Treinta y tres de maestría

Seis de especialidad

Dieciséis de licenciatura

En progreso hay cuatro tesis de alumnos de doctorado y cinco tesis de alumnos de maestría

Líneas de Investigación


Regulación de la expresión génica de los promotores de los sarcoglicanos.

Caracterización de complejos de proteínas asociadas a distrofina/utrofina en distintos tejidos.

Bases moleculares de las distrofias musculares y miocardiopatías.

Estudio de variantes genéticas involucrados en el desarrollo de enfermedades complejas:

  • Estudio de variantes genéticas de genes involucrados en desarrollo de problemas cardiovasculares, cáncer, hipertensión, pie equino varo, preeclampsia, etc.
  • Análisis de la frecuencia de polimorfismos genéticos en población mexicana; indígena y mestiza.


Artículos publicados

ARTICULOS DE INVESTIGACIÓN

1. Ortega-Pierres G, Muñiz E, Coral-Vázquez RM, Parkhouse RM. (1989). Protection against Trichinella spiralis induced by purified stage-specific surface antigens of infective larvae. Parasitology Research, 75:563-567. 10

2. Coral-Vázquez R, Arenas D, Cisneros B, Peñalosa L, Kofman S, Salamanca F, Montañez C. (1993). Análisis of dystrophin gene deletions in patients from the Mexican population with Duchenne/Becker muscular dystrophy. Archives of Medical Research, 24:1-6.

3. Salamana F, Coral R, Peñalosa R, Arenas D, González M, Barrientos C, Buentello L. (1995). Molecular studies of mendelian disorders, embryonic neoplasias, and polymorphisms in selected samples of the general population. A contribution to the genetic characterization of the Mexican population. Archives of Medical Research, 26 (Suppl):S69-S75.  

4. Beattie KL, Beattie WG, Meng L, Turner SL, Coral-Vázquez R, Smith DD, McIntyre PM, Dao DD. (1995). Advances in genosensor research. Clinical Chemistry, 41:700-706. 

5. Arenas D, Coral R, Cisneros B, Peñaloza L, Salamanca F, Kofman S, Mercado R, Méndez J, Martínez , Montañez C. (1996). Carrier detection in Duchenne and Becker muscular dystrophy using dinucleotide repeat polymorphisms. A study in Mexican families. Archives of Medical Research, 27:151-156. 

6. Coral-Vázquez R, Arenas D, Cisneros B, Peñalosa L, Salamanca F, Kofman S, Mercado R, Montañez C. (1997). Pattern of deletions of the dystrophin gene in Mexican Duchenne/Becker muscular dystrophy patients: The use of a new designed primers for the analysis of the major deletion “hot spot” region. American Journal of Medical Genetics, 70:240-246. 

7. Coral-Vázquez R, Cohn RD, Moore SA, Hill JA, Weiss RM, Davisson RL, Straub V, Barresi R, Bansal D, Hrstka RF, Williamson R, Campbell KP. (1999). Disruption of the sarcoglycan-sarcospan complex in vascular smooth muscle: A novel mechanism for cardiomyopathy and muscular dystrophy. Cell, 98:465-474. 

8. Cohn RD, Durbeej M. Steve M, Coral-Vázquez R, Sally P, Campbell KP. (2001). Prevention of cardiomyopathy in mouse models lacking the smooth muscle sarcoglycan-sarcospan complex. Journal Clinical Investigation, 107: R1-R7. 

9. Rodríguez M, Salcedo M, González M, Coral-Vázquez R, Salamanca F, Arenas D. (2002). Identification of novel mutations in the RB1 gene in Mexican patients with retinoblastoma. Cancer Genetics and Cytogenetics, 138(1):27-31. 

10. Rosas-Vargas H, Flores-Segura A, Guizada-Claure B, Vargas-Alarcón G, Granados J, Salamanca F, Coral-Vázquez R. (2003). Endothelial nitric oxide synthase gene polymorphism in the Indian and Mestizo populations of Mexico.. Human Biology,  75(1):91-96.  

11. Coral-Vázquez R, Rosas-Vargas H, Meza-Espinosa P, Mendoza I, Huicochea JC,  Ramón G, Salamanca F. (2003). Severe Congenital Muscular Dystrophy in a Mexican Family with a New Nonsense Mutation (R2578X) in Laminin -2 Gene. Journal of Human Genetics 48:91-95. 

12. Bermúdez-Cruz R, Ortega-Pierres G, Ceja V, Coral-Vázquez R, Fonseca R, Cervantes L, Sánchez A, Newport G, Montañés C. (2004). A 63 kDa VSP9B10-like protein expressed in C-8 Giardia lamblia Mexican clone. Archives of Medical Reserach. 35:199-208. I.I. 1.275. 

13. Rosas-Vargas H, Coral-Vázquez R, Tapia R, Borja JL, Salamanca F. Glu298Asp Endothelial Nitric Oxide Synthase Polymorphism Is a Risk Factor for Erectile Dysfunction in the Mexican Mestizo Population. (2004). Journal of Andrology 25:728-732. I.I. 2.137. 

14. Delgado-Olgín P, Rosas-Vargas H, Recillas-Targa F, Zentella-Dehesa A, Bermúdez de León M, Cisneros B, Salamanca F and Coral-Vázquez R. (2004).  NFI-C2 negatively regulates α-sarcoglycan promoter activity in C2C12 myoblasts. Biochemical and Biophysical Research Communications. 319:1031-1038. I.I. 2.855. 

15. Ramírez-Sánchez I, Rosas-Vargas H, Ceballos G, Salamanca F, Coral-Vázquez R. (2005). Expression analysis of the sarcoglycan-sarcospan complex in the vascular smooth muscle and endothelium. Journal of Vascular Research. 42 :1-7.  I.I. 2.505. 

16. Fort P, Estrada FJ, Bordais A, Mornet D, Sahel JA, Picaud S, Rosas-Vargas H, Coral-Vázquez RM, Rendon A. (2005). The Sarcoglycan-Sarcospan Complex Localization in Mouse Retina is Independent from Dystrophins. Neuroscience Research. 53:25-33. I.I. 1.953. 

17. Estrada FJ, Mornet D, Rosas-Vargas H, Angulo A, Hernández M, Becker V, Coral-Vázquez RM. (2006). A novel isoform of murine Delta-sarcoglycan localized in sarcoplasmic reticulum. Biochemical and Biophysical Research Communications 340:865-871. 

18. Delgado-Olguín P, Recillas-Targa F, Rosas-Vargas H, Salamanca F, Coral-Vázquez R. (2006). Partial characterization of the mouse α-sarcoglycan promoter and its responsiveness to MyoD. Biochimica et Biophysica Acta, Gene Structure and Expression. 1759:240-246. 

19. Ramírez-Sánchez I, Ceballos-Reyes G, Rosas-Vargas H, Cerecedo-Mercado D, Salamanca Fabio, Coral- Vázquez RM. (2007). Expression and function of utrophin associated protein complex in stretched endothelial cells: dissociation and activation of eNOS. Frontiers in Bioscience 12:1956-1962. 

20. Romo-Yáñez J,  Ceja V, Ilarraza-Lomelí R, Coral-Vázquez R, Velázquez F, Mornet D, Rendón A and Montañez C. (2007). Dp71ab/DAPs complex composition changes during the differentiation process in PC12 cells. Journal of Cellular Biochemistry. 102(1):82-97. 

21. Canto-Cetina T, Canizales-Quinteros S, de la Chesnaye E, Coral-Vázquez R, Méndez JP, Canto P. (2007). Análisis of C-850T and G-308A polymorphisms of the tumor necrosis factor-a gene in Maya-Mestizo women with preeclampsia. Hypertension in Pregnancy. 26:283-291.

22. Canizales-Quinteros S, Aguilar-Salinas CA, Ortiz-López G, Rodríguez-Cruz M, Villarreal-Molina MT, Coral-Vázquez R, Huertas-Vázquez A, Hernández-Caballero A, López-Alarcón M, Brito-Zurita OR, Domínguez-Banda A, Martinez-Sánchez LR, Canto-de Cetina T, Vilchis-Dorantes G, Rosas-Vargas H,. Granados-Silvestre MA, Medeiros-Domingo A, Menjivar M, Tusié-Lun MT. (2007). Association of PPAR2 Pro12Ala Variant with Larger Body Mass Index in Mestizo and Amerindian Populations of Mexico. Human Biology. 78:111-119. 

23. Rosas-Vargas H, Gómez-Díaz B, Ruano-Calderón L, Fernández-Valverde F, Roque-Ramírez B, Portillo-Bobadilla T, Ordoñez-Razo RM, Minauro-Sanmiguel F, Coral-Vázquez R. (2007). Dysferlin homozygous mutation G1418D causes limb-girdle type 2B in a Mexican family. Genetic Testing 11(4):391-396. 

24. Villarreal-Molina MT, Aguilar-Salinas CA, Rodríguez-Cruz M, Riaño D, Villalobos-Comparán M, Coral-Vázquez R, Menjivar M, Yescas-Gómez P, Könisberg-Feinstein M, Romero-Hidalgo S., Tusié-Luna MT, Canizales-Quinteros S, and the Metabolic Study Group. (2007). The ATP-binding cassette transporter A1 R230C variant affects HDL cholesterol levels and BMI in the Mexican population: association with obesity and obesity-related comorbidities. Diabetes. 56:1881-1887. 

25. Canizales-Quinteros S, Aguilar-Salinas CA, Ortiz-López MG, Rodríguez-Cruz M, Villarreal-Molina MT, Coral-Vázquez R, Huertas-Vázquez A, Hernández-Caballero A, López-Alarcón M, Brito-Zurita OR, Domínguez-Banda A, Martinez-Sánchez LR, Canto-de Cetina T, Vilchis-Dorantes G, Rosas-Vargas H, Granados-Silvestre MA, Medeiros-Domingo A, Menjivar M, Tusié-Luna MT. (2007). Association of PPARG2 Pro12Ala variant with larger body mass index in Mestizo and Amerindian populations of Mexico. Hum Biol. 79:111-119.

26. Villarreal-Molina MT, Flores-Dorantes MT, Arellano-Campos O, Villalobos-Comparan M, Rodríguez-Cruz M, Miliar-García A, Huertas-Vazquez A, Menjivar M, Romero-Hidalgo S, Wacher NH, Tusie-Luna MT, Cruz M, Aguilar-Salinas CA, Canizales-Quinteros S; Metabolic Study Group. (2008). Association of the ATP-binding cassette transporter A1 R230C variant with early-onset type 2 diabetes in a Mexican population. Diabetes. 57:509-513. 

27. Rodriguez-Cruz M, Sanchez R, Arenas D, Coral-Vazquez R, Velázquez AC, Ramón-García G, Siordia G, Salamanca F, Salcedo M. (2008). pRB expression a common event in human retinoblastomas: An immunohistochemistry study. Acta Histochemica 110:109-116. 

28. Delgado-Olguín P, Hernández-Hernández JM, Recillas-Targa F, Salamanca F, Coral-Vázquez RM. (2008). Identification of two E-boxes that negatively modulate the activity of MyoD on the alpha-sarcoglycan promoter. Biochimica et Biophysica Acta, Gene Regulatory Mechanisms 1779:74-80. 

29. Canto P, Canto-Cetina T, Juárez-Velázquez R, Rosas-Vargas H, Rangel-Villalobos H, Canizales-Quinteros S, Velázquez-Wong AC, Villarreal-Molina, MT, Coral-Vázquez R. (2008). Methylenetetrahydrofolate reductase C-667T and Glutathione S transferase P1 A-313G are associated with a reduced risk of preeclampsia in Maya-Mestizo women. Hypertension Research 31:1015-1019. 

30. Sánchez-Moreno I, Coral-Vázquez  R, Méndez  J, Canto P. (2008). A full length SRY protein is Essentials for DNA binding. Molecular Human Reproduction 14:325-30. 

31. Velázquez-Wong A, Hernández-Huerta C, Márquez Calixto A, Hernández-Aguilar FO, Rodríguez-Cruz M, Salamanca-Gómez F, Coral-Vázquez R. (2008). Identification of Duchenne Muscular Dystrophy female carriers by fluorescent in situ hybridization and RT-PCR. Genetic Testing 12:221-223. 

32. Villalobos-Comparán M, Teresa Flores-Dorantes M, Teresa Villarreal-Molina M, Rodríguez-Cruz M, García-Ulloa AC, Robles L, Huertas-Vázquez A, Saucedo-Villarreal N, López-Alarcón M, Sánchez-Muñoz F, Domínguez-López A, Gutiérrez-Aguilar R, Menjivar M, Coral-Vázquez R, Hernández-Stengele G, Vital-Reyes VS, Acuña-Alonzo V, Romero-Hidalgo S, Ruiz-Gómez DG, Riaño-Barros D, Herrera MF, Gómez-Pérez FJ, Froguel P, García-García E, Teresa Tusié-Luna M, Aguilar-Salinas CA, Canizales-Quinteros S. (2008). The FTO gene is associated with class III adulthood obesity in the Mexican population. Obesity 16:2296-301. 

33. Hernández-Hernández JM, Delgado-Olguín P, Aguillón-Huerta V, Furlan-Magaril M, Recillas-Targa F and. Coral-Vázquez RM. (2009). Sox9 represses alpha-sarcoglycan gene expression in early myogenic differentiation. Journal Molecular Biology. 39(1) :1-14. 

34. Estrada-Mena B, Estrada J, Ulloa-Arvizu R, Guido M, Méndez R, Coral R,  Canto T, Granados J, Rubí-Castellanos R, Rangel-Villalobos H, García-Carrancá A. (2010). Blood Group O Alleles in Native Americans: Implications in the Peopling of the Americas. American. Journal of Physical Anthropology 142:85-94. 

35. Solares-Pérez A, Sánchez JA, Zentella-Dehesa A, García MC, Coral-Vázquez RM. (2010). Intracellular Ca2+ transients in -Sarcoglycan Knockout Mouse Skeletal Muscle. Biochemical Biophysical Acta, General Subjects. 1800:373-9. JCR IF=5

36. Ordoñez-Razo RM, Canizales-Quinteros S, Rodríguez-Cruz M, Peñaloza R,. Minauro-Sanmiguel F, Canto-Cetina T, Canto P., Coral-Vázquez R. (2010). Delta Sarcoglycan gene polymorphism frequency in Amerindian and mestizo populations of Mexico. Genetic Testing and Molecular Biomarkers. 14:237-40. 

37. Martínez-Cortes G,  Nuño-Arana I, Rubi-Castellanos R, Vilchis-Dorantes G, Luna-Vazquez A, Coral-Vazquez RM, Canto-Cetina T, Salazar-Flores J, Romero-Renteria O, Sandoval K, Muñoz-Valle J, Gamero J, Rangel-Villalobos H. (2010). Origin and Genetic Differentiation of Three Mexican Native Groups (Purépechas, Triquis, and Mayas): Contribution of CODIS-STRs to the History of Human Populations of Mesoamerica. Annals Human Biology 142(1):85-94. 

38. Juárez-Velázquez R, Canto P, Canto-Cetina T, Rosas-Vargas H, Canizales-Quinteros S, Rangel-Villalobos H, Velázquez-Wong AC, Coral-Vázquez RM. (2010). Analysis of polymophisms in in thrombophilic and analysis of polymorphisms in trombophilic and hypertension (AGT, GPIIIa, MTHFR and GST). Disease Markers 28(5):323-331. 

39. Solares-Pérez A, Álvarez R, Crosbie H, Ortega A, Coral-Vazquez RM. (2010). Altered Calcium Pump and Secondary deficiency of -sarcoglycan and Microspan in Sarcoplasmic Reticulum membranes isolated from -sarcoglycan knockout mice. Cell Calcium 48(1):28-36. 

40. Rojano-Mejía D, Aguilar-Madrid G, López-Medina G, Cortes Espinosa L, Hernández Chiu MC, Canto-Cetina T, Vergara-López A, Coral-Vázquez RM, Canto P. (2011). Risk factors and impact on bone mineral density IN postmenopausal Mexican Mestizo Women. Menopause 18(3):302-306. 

41. Vargas-Alarcón G, Granados J, Pérez-Hernández N, Rodríguez-Pérez1 JM, Canto-Cetina T, Coral-Vázquez RM, Areces C, Gómez-Prieto P, Arnaiz-Villena A. (2011). HLA-class II genes in Mexicans Amerindian Mayas: relatedness with Guatemalan Mayans and other populations. Immunological Investigations. 40(1):101-111. 

42. López-Hernández LB2, Van Heusden D, Soriano-Ursúa MA,  Figuera-Villanueva L, Vázquez-Cárdenas NA, Sandoval-Ramírez L, Canto P, Gómez-Díaz B, Coral-Vázquez RM. (2011). Genotype-phenotype discordance in Duchenne Muscular Dystrophy patient due to a novel mutation: insights into the shock absorber function of dystrophin. Revista de Neurología 52(12):720-724. 

43. Blanca E García-Pérez, Daniela A Villagómez-Palatto, Jorge I Castañeda-Sánchez, Ramón M Coral-Vázquez, Israel Ramírez-Sánchez, Rosa M Ordoñez-Razo, Julieta Luna-Herrera. (2011). Innate response of human endothelial cells infected with mycobacteria. Immunobiology 216(8):925-935.   

44. Díaz-Olguín L, Coral-Vázquez RM, Canto-Cetina T, Canizales-Quinteros S, Ramírez Regalado B, Fernández G, Canto P. (2011). Endothelial nitric oxide synthase gene haplotypes are associated with preeclpamsia im Maya-Mestizo women. Disease Markers 31(2):83-9. 

45. Rojano.Mejía D, Coral-Vázquez RM, Cortes Espinosa L, Romero-Hidalgo S,    López-Medina G, Aguirre-García MC, Coronel A, Ibarra R, Vergara-López A, Canto P. (2012). TNFRSF 11B gene haplotype and its association with bone mineral density variations in postmenopausal Mexican-Mestizo women. Maturitas 71:49-54. 

46. Gómez-Díaz B, Meza-Espinoza P, Rosas-Vargas H, Roque-Ramírez B, A Ruano-Calderón L, Fernández-Valverde F, Escalante-Bautista D, E Escobar-Cedillo R, Sánchez-Chapul L, Vargas-Cañas S, López-Hernández LB, Bahena-Martínez E, Luna-Angulo A, Canto P, Coral-Vázquez RM. (2012). Immunodetection analysis of muscular dystrophies in Mexico. Muscle and Nerve. 45:338-345. 

47. Ramírez-Sánchez I, Mendoza-Lorenzo P, Zentella-Dehesa A, Méndez-Bolaina E, Lara-Padilla E, Ceballos-Reyes G, Canto P, Palma-Flores C, Coral-Vázquez RM. (2012). Caveolae and non caveolae lipid rafts microdomains of HUVEC contain utrophin associated protein complexes. Biochimie 94:1884-1890. 

48. Reich D, Patterson N, Campbell D, Tandon A, Mazieres S, Ray N, Parra MV, Rojas W, Duque C, Mesa N, García LF, Triana O, Blair S, Maestre A, Dib JC, Bravi CM, Bailliet G, Corach D, Hünemeier T, Bortolini MC, Salzano FM, Petzl-Erler ML, Acuña-Alonzo V, Aguilar-Salinas C, Canizales-Quinteros S, Tusié-Luna T, Riba L, Rodríguez-Cruz M, Lopez-Alarcón M, Coral-Vazquez R, Canto-Cetina T, SilvaZolezzi I, Fernandez-Lopez JC, Contreras AV, JimenezSanchez G, Gómez-Vázquez MJ, Molina J, Carracedo A, Salas A, Gallo C, Poletti G, Witonsky DB, Alkorta-Aranburu G, Sukernik RI, Osipova L, Fedorova S, Vasquez R, Villena M, Moreau C, Barrantes R, Pauls D, Excoffier L, Bedoya G, Rothhammer F, Dugoujon JM, Larrouy G, Klitz W, Labuda D, Kidd J, Kidd K, Rienzo AD, Freimer NB, Price AL, Ruiz-Linares A. (2012). Reconstructing Native American Population History. Nature 488:370-374.

49. Vázquez-Cárdenas NA, Ibarra-Hernández F, López-Hernández LB, Escobar-Cedillo RE, Ruano-Calderón LA, Gómez-Díaz B, García-Calderón N, Carriedo-Dávila MF, Rojas-Hurtado LG, Luna-Padrón E, Coral-Vázquez RM. (2013). Diagnosis and treatment with steroids for patients with Duchenne muscular dystrophy: experience and recommendations for Mexico. Administración del Patrimonio de la Beneficencia Pública. Asociación de Distrofia Muscular de Occidente. Rev Neurol. 16;57(10):455-462.

50. Valencia Villalvazo EY, Canto-Cetina T, Romero Arauz JF, Coral-Vázquez RM, Canizales-Quinteros S, Coronel A, Carlos Falcón J, Hernández Rivera J, Ibarra R, Polanco Reyes L, Canto P. (2012). Analysis of polymorphisms in interleukin-10, interleukin-6 and interleukin-1 receptor antagonist in mexican-mestizo women with preeclampsia. Genet Test Mol Biomarkers.16:1263-1269. 

51. Rojano-Mejía D, Coral-Vázquez RM, Cortes Espinosa L, López-Medina G, Aguirre-García MC,  Coronel A, Canto P. (2013). JAG1 and COL1A1 polymorphisms and haplotypes in relation to bone mineral density variations in postmenopausal Mexican mestizo women. Age 35:471-48. 

52. Coral-Vázqueza RM, Romero Arauz JF, Canizales-Quinteros, Coronel A, Valencia Villalvazoe EY, Hernández Rivera J, Ramírez Regalado B, Rojano Mejía D, Canto P. (2013). Analysis of polymorphisms and haplotypes in genes associated with vascular tone, hypertension and oxidative stress in mexican-mestizo women with severe preeclampsia. Clinical Biochemistry 46:627-632.  

53. Pam R. Taub, Israel Ramirez-Sanchez, Theodore P Ciarald, Silvia Gonzalez-Basurto, Ramon Coral-Vazquez, Guy Perkins, Michael Hogan, Alan S. Maisel, Robert R. Henry, Guillermo Ceballos, Francisco Villarreal. (2012). Perturbations in skeletal muscle sarcomere structure of heart failure and type 2 diabetes patients: Restorative effects of (-)-epicatechin-rich cocoa. Clinical Science. 125:383-9. 

54. Méndez JP, Rojano-Mejía D, Pedraza, J., Coral-Vázquez RM, Soriano R, García-García E, Aguirre-García MC, Coronel A, Canto P. (2013).  Bone mineral density in postmenopausal mexican-mestizo women with normal body mass index, overweight or obesity. Menopause 20:568-572. 

55. Castro JJ, Méndez JP, Coral-Vázquez RM, Soriano-Ursúa MA, Damian-Matsumurae P, Benítez- Granados H, Rosas-Vargas H, Canto P. (2013). In vitro and molecular modeling analysis of two mutant desert hedgehog (dhh) proteins associated with 46 XY gonadal dysgenesis. DNA and Cell Biology 32:524-530

56. Méndez JP Rojano-Mejía D, Coral-Vázquez RM, Coronel A, Pedraza J, Casas MJ, Soriano R, García-García E, Vilchis F, Canto P. (2013). Impact of genetic variants of Il-6, Il6r, Lrp5, Esr1 and Sp7 genes on bone mineral density in postmenopausal mexican-mestizo women with obesity. Gene. 528:216-220. 

57. Canto-Cetina T, Polanco Reyes L, González Herrera L, Rojano-Mejía D, Coral-Vázquez RM, Coronel A, Canto P. (2013). Polymorphism of LRP5, but not of TNFRSF11B, is associated with a decrease in bone mineral density in postmenopausal Maya-Mestizo women. Am J Hum Biol. 5(6):713-718.

58. Rodriguez-Cruz M, Coral-Vazquez R, Hernández-Stengele G, Sanchez R, Salazar E, Sánchez-Muñoz F, Encarnación-Guevara S, Ramírez J. (2013). Identification of putative ortholog gene blocks involved in gestant and lactating mammary gland development: A rodent cross-species microarray transcriptomics approach. International Journal of Genomics 2013: article ID 624681, 12 pages.

59. Escobar-Cedillo RE, Tintos-Hernández JA, Martínez-Castro G, Montes de Oca-Sánchez B, Rodríguez-Jurado R, Miranda-Duarte A, Gómez-Díaz B, Coral-Vázquez RM, García S, López-Hernández LB. (2013). L-carnitine supplementation in duchenne muscular dystrophy steroid naïve patients: a pilot study. Current Topics in Nutraceutical Research 11:97-101. 

60. Rojano-Mejía D, Coral-Vázquez RM, Coronel A, Cortes-Espinosa L, Aguirre-García MG, Valencia-Villalvazo EY, Canto P. (2014).  Relation of the estrogen receptor and vitamin d receptor polymorphisms with bone mineral density in postmenopausal mexican-mestizo women.  Gene 537:10-14

61. López-Hernández LB, Bahena-Martínez E, Gómez-Díaz B, Neri-Gómez T, Camacho-Molina A, Ruano-Calderón LA, García S, Coral-Vázquez RM. (2014). A novel non-contiguous duplication in the DMD gene escapes the "reading-frame rule". Journal of Genetics 93:225-229. 

62. García S, López-Hernández LB, Suarez-Cuenca JA, Solano-Rojas M, Gallegos-Arreola MP, Gama-Moreno O, Valdez Anguiano P, Canto P, Dávila-Maldonado L, Cuevas-García CF, Coral-Vázquez RM. (2014). Low prevalence of most frequent pathogenic variants of six park genes in sporadic Parkinson´s disease. Folia Neuropathol 52:22-29.

63. Palma-Flores C, Ramírez-Sánchez I, Rosas-Vargas H, Canto P, CoraL-Vázquez RM. (2014). Description of a new utrophin-associated protein complex in caveolae domains of human artery smooth muscle cells. Biochemical Biophysical Acta, Biomembranes 1838:1047-1054.

64. López-Hernández LB, Gómez-Díaz B, Escobar-Cedillo RE, Gama-Moreno O, Camacho-Molina A, Soto-Valdés DM, Anaya-Segura MA, Luna-Padrón E, Zúñiga-Guzmán C, López-Hernández JA, Vázquez-Cárdenas NA, Sánchez-Chapul L, Rangel-Villalobos H, Canto P, López-Cardona MG, García S, Méndez-Covarrubias G, Coral-Vázquez RM. (2014). Duchenne muscular dystrophy in a developing country: challenges in management and genetic counseling. Genetic Counseling 25:129-141.

65. Roque-Ramírez B, Chimal-Monroy J, Canto P, Coral-Vázquez RM. (2014). Expression Pattern of mRNA A and mRNA B of Alpha Sarcoglycan Gene during Mouse Embryonic Development and Regulation of Their Expression by Myogenic and Cardiogenic Transcription Factors. Developmental Dynamics 243:1416-1428. 

66. Ramirez-Sanchez I, De Los Santos S, Gonzalez-Basurto S, Canto P, Mendoza-Lorenzo P, Palma-Flores C, Ceballos-Reyes G, Villarreal F, Zentella-Dehesa A, Coral-Vazquez R. (2014). (-)-Epicatechin improves mitochondrial-related protein levels and ameliorates oxidative stress in dystrophic δ-sarcoglycan null mouse striated muscle. FEBS J 281:5567-5580.

67. Hernández-Reséndiz S, Palma-Flores C, De los Santos S, Flores M, de la Peña A, Flores PL, Fernández-G JM, Coral-Vázquez RM and Zazueta C. (2015). Reduction of no-reflow and reperfusion injury with the Synthetic 17β-aminoestrogen compound Prolame is associated with PI3K/Akt/eNOS signaling cascade. Basic Res Cardiology 110:1-12

68. García S, Coral-Vázquez RM, Gallegos-Arreola MP, Montes-Almanza LA, Canto P, García-Martínez FA, Chavira- Hernández G, Palma-Flores C, Dávila-Maldonado L, Cuevas-García CF, López Hernández LB. (2015). Association of the rs1801133 variant in the MTHFR gene and Sporadic Parkinson´s Disease. Folia Neuropathologica. 53:24-28.

69. López-Hernández LB, Gómez-Díaz B, Luna-Angulo AB, Anaya-Segura M, Bunyan DJ, Zúñiga-Guzman C, Escobar-Cedillo RE, Roque-Ramírez B, Ruano-Calderón LA, Rangel-Villalobos H, López-Hernández JA, Estrada-Mena FJ, García S, Coral-Vázquez RM. (2015).  Comparison of mutation profiles in the Duchenne Muscular Dystrophy gene among populations: implications for potential molecular therapies. International Journal of Molecular Sciences. 16:5334-5346.

70. Rodríguez-Cruz M, Sanchez R, Escobar RE, Cruz-Guzmán OR, López-Alarcón M, Bernabe-García M, Coral-Vázquez R, Matute G, Velázquez-Wong AC. (2015).  Evidence of Insulin Resistance and Other Metabolic Alterations in Boys with Duchenne or Becker Muscular Dystrophy. International Journal of Endocrinology.  2015: 2015:867273, 8 pages.

71. García-Romeroa CS, Akaki-Caballero M, Saavedra-Mendozab AG, Guzmán-Romero AK, Canto P, Coral-Vázquez RM. (2015). Molecular subtypification of human papillomavirus in male adult individuals with recurrent respiratory papillomatosis. Auris Nasus Larynx. 42:385-389.

72. Méndez JP, Zenteno JC, Corone A, Soriano Ursúa MA, Valencia-Villalvazo EY, Soderlund D, Coral-Va´zquez RM, Canto P. (2014). Triallelic digenic mutation in the prokineticin 2 and gnrh receptor genes in two brothers with normosmic congenital hypogonadotropic hypogonadism. Endocrine Research. 40:166-171. 

73. Canto-Cetina T, Cetina Manzanilla JA, González Herrera L, Rojano-Mejía D, Coral-Vázquez RM, Coronel A, Canto P.  (2015). VDR polymorphisms are associated with bone mineral density in post-menopausal Mayan-Mestizo women. Ann Hum Biol 42:470-475. 

74. Anaya-Segura MA, García-Martínez FA, Montes-Almanza LA, Gomez Díaz B, Ávila-Ramírez G, Álvarez-Maya I, Coral-Vázquez RM, Mondragón-Terán P, Escobar-Cedillo RE, Vazquez-Cardenas NA, García S, López-Hernandez LB. (2015). Non-Invasive Biomarkers for Duchenne Muscular Dystrophy and Carrier Detection. Molecules. 20:11154-11172.

75. Pérez-Razo JC, Cano-Martínez LJ, Vargas Alarcón G, Canizales-Quinteros S, Martínez-Rodríguez N, Canto P, Roque-Ramírez B, Palma-Flores C, Esteban-Martínez R, López-Hernández B, Rojano-Mejía D, Coral-Vázquez RM. (2015). Functional polymorphism rs13306560 of the MTHFR gene is associated with essential hypertension in a Mexican-Mestizo population. Circulation, Cardiovascular Genetics. 8:603-609.

76. Esteban-Martínez RL, Pérez-Razo JC, Vargas-Alarcón G, Martínez-Rodríguez N, Cano-Martínez LJ, López-Hernández LB, Rojano-Mejía D, Canto P, Coral-Vázquez RM. (2016). Polymorphisms of APLN-APLNR system are associated with essential hypertension in Mexican-Mestizo individuals. Experimental Molecular Pathology. 101:105-109.

77. Sánchez-Chapul L, Del Ángel-Muñoz M, Ruano-Calderón L, Luna-Angulo A, Coral-Vázquez R, Hernández-Hernández Ó, Magaña JJ, León-Hernández SR, Escobar-Cedillo RE, Vargas S. (2016). Quantification of dysferlin in monocytes for rapid screening for dysferlinopathies. Muscle Nerve. 54:1064-1071.

78. Anaya-Segura MA, Rangel-Villalobos H, Martínez-Cortés G, Gómez-Díaz B, Coral-Vázquez RM, Zamora-González EO, García S, López-Hernández LB. (2016). Serum levels of microRNA-206 and novel Mini-STR assays for carrier detection in Duchenne muscular dystrophy. International Journal of Molecular Science. 17(8). pii: E1334. 

79. Velázquez-Macías RF, De La Torre-Rendón FE, Ramos-Rodríguez G, Calzada-Mendoza CA, Coral-Vázquez RM (2016). Bcl2 in advanced prostate cancer and its association with castration resistance. | [Bcl2 en cáncer avanzado de próstata y asociación con resistencia a la castración]. Revista Mexicana de Urología 6(5):288-293.

80. De los Santos S, García-Pérez V, Hernández-Reséndiz S, Palma-Flores C, González-Gutiérrez CJ, Zazueta C, Canto P, Coral-Vázquez RM. (2017). (-)-epicatechin induces physiological cardiac growth by activation of the pi3k/akt pathway in mice. Molecular Nutrition and Food Research. 61(2):1-10

81. Peter AK, Miller G, Capote J, DiFranco M, Solares-Pérez A, Wang EL, Heighway J, Coral-Vázquez RM, Vergara J, Crosbie-Watson RH. (2017). Nanospan, an alternatively spliced isoform of sarcospan, localizes to the sarcoplasmic reticulum in skeletal muscle and is absent in limb girdle muscular dystrophy 2F. Skeletal Muscle 7(1):1-17.

82. Chávez B, Vilchis F, Rojano-Mejía D, Coral-Vázquez RM, Aguirre-García MC, Canto P. (2017). Association of CYP1A1 and CYP1B1 polymorphisms with bone mineral density variations in postmenopausal Mexican-mestizo women. Gynecological Endocrinology. 33(8):607-610.

83. Posadas-Sánchez R, Pérez-Hernández N, Rodríguez-Pérez JM, Coral-Vázquez RM, Roque-Ramírez B, Llorente L, Lima G, Flores-Domínguez C, Villarreal-Molina T, Posadas-Romero C, Vargas-Alarcón G. (2017). Interleukin-27 polymorphisms are associated with premature coronary arterial disease and metabolic parameters in the Mexican population: The Genetics of Atherosclerotic Disease (GEA) study. Oncotarget. 8(38):64459-64470.

84. Canto P, Benítez Granados J, Feria-Bernal G, Coral-Vázquez RM, García-García E, Tejeda ME, Tapia A, Rojano-Mejía D, Méndez JP. (2017). PPARGC1A and ADIPOQ polymorphisms are associated   with aggressive prostate cancer in mexican-mestizo. men with overweight or obesity. Cancer Biomarkers 19:297-303.

85. García S, Cano-Martínez LJ, Coral-Vázquez RM, Coronel-Pérez A, Gómez-Díaz B, Toledo-Lozano CG, Gallegos-Arreola MP, Dávila-Maldonado L, Jiménez-Hernández DA, Alcaraz-Estrada SL, López-Hernández LB. (2017). Analysis of the rs13306560 functional variant in the promoter region of the MTHFR gene in sporadic Parkinson´s disease. Neuroendocrinol Lett. 38(4):257-260.

86. Castillo-Hernández MC, Guevara-Balcazar G, Kormanovski A, Rubio Gayosso I, Coral-Vazquez RM. (2017). Changes in vascular reactivity of the coronary artery and thoracic aorta in the delta sarcoglycan null mutant mice. Physiology and Pharmacology. 21(4): 322-330.

87. Esquitin-Garduño N, Escobar-Cedillo RE, Flores-Avalos B G, Escobar-Cedillo G, Miranda-Duarte A, López-Hernández LB, Orellana-Villazón VI, Coral-Vázquez RM, García S, Gómez-Díaz B. (2017). Cognitive Event-Related Potentials (P300) and Cognitive Impairment in Duchenne Muscular Dystrophy. Neurophysiology 49:357-362.

88. Martínez-Ramírez M, Coral-Vázquez RM, Tenorio A, Méndeza JP, Benítez-Granados J, Maffuz Asis A, Rodríguez-Cuevas S, Domínguez-Reyes C, Erazo-Valle A, Canto P. (2018). Complete sequence of the ATP6 and ND3 mitochondrial genes in breast cancer tissue of postmenopausal women with different body mass indexes.  Annals of Diagnostic Pathology 32:23-27.

89. Canto-Cetina T, Coral-Vázquez RM, Rojano-Mejía D, Pérez Godoy S, Coronel A, Canto. (2018). Higher pregnancy body mass index is a risk factor for developing preeclampsia in Maya-mestizo women: a cohort study. Ethnicity and Health 23:682-690. 

90. López-Hernández B, Méndez JP, Benítez-Granados J, Coral-Vázquez RM, Zenteno JC, Villegas-Ruiz V, Calzada-León R, Soderlund D, Canto P. (2018). Duplication of sox9 associated with 46, XX ovotesticular disorder of sex development. Reproductive BioMedicine Online 37:107-112.

91. Cano-Martínez LJ, Coral-Vázquez RM, Méndez JP, Trejo S, Pérez-Razo JC, Canto P. (2018). Serum concentrations of apelin-17 isoform vary in accordance to blood pressure categories in individuals with obesity class 3. Clinical and Experimental Hypertension. En prensa. 

92. De los Santos S, Palma-Flores C, Zentella-Dehesa A, Canto P, Coral-Vázquez RM. (2018). ()-Epicatechin inhibits development of dilated cardiomyopathy in δ sarcoglycan null mouse. Nutrition, Metabolism & Cardiovascular Diseases. 28:1188-1195.

93. Muñoz-Vega M, Massó F, Páez A, Vargas-Alarcón G, Coral-Vázquez R, Mas-Oliva J, Carreón-Torres E, Pérez-Méndez Ó. (2018). HDL-Mediated Lipid Influx to Endothelial Cells Contributes to Regulating Intercellular Adhesion Molecule (ICAM)-1 Expression and eNOS Phosphorylation. Int J Mol Sci. 19(11). pii: E3394. 

94. Posadas-Sánchez R, Roque-Ramírez B, Rodríguez-Pérez JM, Pérez-Hernández N, Fragoso JM, Villarreal-Molina T, Coral-Vázquez R,. Tejero ME, Posadas-Romero C, Vargas-Alarcón G. (2018). Raet1e polymorphisms are associated with increased risk of developing premature coronary artery disease and with some cardiometabolic parameters. GEA Mexican Study. Mediators of Inflammation. En prensa.



ARTICULOS DE REVISIÓN

1. Coral-Vázquez R, Salamanca-Gómez F (1996). Biología molecular de la distrofia muscular de Duchenne. Gaceta Médica de México, 132:221-222.   

2. Coral-Vázquez R, Navarrete-Cadena C, Mendoza-Camarillo I, Barraza-García A, Salamanca-Gómez F. Avances en distrofias musculares. (2000). Revista Médica-IMSS, 38:155-164.  

3. García S, Coral Vázquez RM, Meza Dávalos E, Lucino Castillo J, Martínez Silva B, Villagómez Ortiz AJ. (2009). Enfermedad de Alzheimer: una panorámica desde su primera descripción hacia una perspectiva molecular. Med Int Mex,  25(4):300-312.

4. García S, López B, Meza-Dávalos E, Villagómez-Ortiz AJ, Coral-Vázquez R. (2010). Breve reseña histórica de la enfermedad de Parkinson. De la descripción precipitada de la enfermedad en el siglo XIX, a los avances en Biología Molecular del padecimiento. Med Int Mex 26(4):350-373.

5. Coral-Vázquez RM, López-Hernández LB, Ruano-Calderón LA, Gómez-Díaz B, Fernández-Valverde F, Bahena-Martínez E. (2010). Distrofias Musculares en México: Un enfoque Clínico, Bioquímico y Molecular. Revista de Especialidades Médico-Quirúrgicas 15(3):152-160. 

6. López-Hernández LB, Ayala-Madrigal ML, van Heusden D, Estrada-Mena FJ, Canto P, Sandoval-Ramírez L, Gómez-Díaz B, Coral-Vázquez RM. (2011). Improvements in Dystrophinopathy Diagnosis: What have we learned after 20 years? Revista de Neurología. 52(4):239-249. 


CAPITULOS EN LIBROS

1. Ortega-Pierres MG, Lascurain R, Arguello-García R, Coral-Vázquez R, Acosta G, Santos JI. (1988). The response of humans to antigens of Giardia lamblia. En Advancces in Giardia Research. Ed. PM Wallis & BR Hammond, University of Calgary Press, Calgary.

2. Coral-Vázquez R, Salamanca-Gómez F, Buentello-Malo L. (1995). Aportación del ADN mitocondrial en el estudio filogenético de las poblaciones indígenas de América. En Anales de Antropología. Ed Instituto de Investigaciones Antropológicas-UNAM.  pp 73-82. 

3. Coral R. (1997). ADN en el estudio de las poblaciones Amerindias. En Estudio Demográfico y Genético de los migrantes al medio urbano. Ed Instituto de Investigaciones Antropológicas-UNAM. pp 29-32.

4. Navarrete-Cadena C, Coral-Vázquez RM. (1999). Distrofia muscular progresiva seudohipertrófica tipo Duchenne/Becker. En Guizar-Vázquez JJ, Zafra de la Rosa GF. Diagnóstico de síndromes genéticos. Ed Manual Moderno, México. pp 276-281.

5. Coral-Vázquez RM. (1999). Aplicación de la Biología Molecular en Genética Clínica.  En Guizar-Vázquez JJ, Zafra de la Rosa GF. Diagnóstico de síndromes genéticos. Ed Manual Moderno, México. pp 20-23. 

6. Coral-Vázquez Ramón Mauricio (2001). Terapia Génica. En Guizar-Vázquez JJ. Genética Clínica: Diagnóstico y manejo de las enfermedades hereditarias. Ed. Manual Moderno, 3ª ed. pp 729-736. 

7. Cecilia Montañez, Rosa María Bermúdez-Crúz, Ramón Coral-Vázquez, Diego Arenas, Laura Peñalosa y Alvaro Rendón. (2009). La distrofia muscular de Duchene: Aspectos clínicos y moleculares. En Neurobiología de los trastornos neuropsiquiátricos  más prevalente en México. Editorial Roco. México. 

Información Académica


Postdoctorado en Laboratorio del Dr. Kevin Campbell. Howard Hughes Medical Institute, Iowa University, Iowa. USA

Dr en Ciencias, especialidad Genética y Biología Molecular. Centro de Investigación y de Estudios Avanzados IPN (CINVESTAV-IPN)

M en Ciencias, especialidad Biología Molecular. Centro de Investigación y de Estudios Avanzado IPN (CINVESTAV-IPN)

Licenciatura en Biología. Facultad de Estudios Superiores Iztacala-UNAM (FES Iztacala-UNAM)

Miembro del Sistema Nacional de Investigadores (Nivel III)